Dominic Sisti & Monica Calkins
Schizophrenia and other psychosis spectrum disorders do not develop de novo but emerge from prodromal stages that are named and operationalized differently depending on the research group or consortium and its theoretical orientation. As a result, a complex lexicon now exists for characterizing individuals’ risk of subclinical symptoms converting to psychosis. Researchers aim to develop instruments and methods to identify people at risk of psychosis, better understand their risks, and offer preventative treatments to arrest conversion to psychosis; ethical and policy questions loom large with each of these projects. In this paper, we canvass the lexical complexities of the at-risk status for psychosis and then consider ethical and policy challenges that researchers and clinicians face in disclosing, preventing, and treating psychosis risk.
HIGH IMPACT PAPERS
Australian Broadcast Corporation | "Controversial ketamine clinic linked to sex treatment company as medical board launches investigation" | June 15, 2015 | Read Article
The Atlantic | "Who Decides Where Autistic Adults Live?" | May 26, 2015 | Read Article
VICE | "The Life, Death, and Possible Resurrection of the Asylum" | April 27, 2015 | Read Article
The New York Times | "The Modern Asylum" | February 18, 2015 | Read Article
Nature | "Rave drug holds promise for treating depression fast" | January 7, 2015 | Read Article
Amy Lutz | The Atlantic | May 26, 2015
"We were trying to rehabilitate the term [asylum], bring it back to its original meaning, which is a place of sanctuary and healing,” Sisti said. “But it turned out to be too distracting. Everyone focused on that instead of the ethical imperative, which is clear: We need settings that match up with each individual’s needs.”
Anson Koshy & Dominic Sisti | The Journal of Medical Ethics
Ethical debates about the origins, status, and treatment of ADHD have been happening for decades. We argue that assent for ADHD related treatment can be a valuable clinical tool for clinicians in promoting aspects of shared decision making, family centered care and supporting the transition of care to adulthood. Meaningful assent requires an ongoing process and dialogue between all parties involved in the medical decision-making of a child’s health.
February 27, 2015
Dominic Sisti, Joseph Rogers, Michael Brody, Andrea Segal | The Public's Health
Mental health care in the United States continues to be under-resourced, plagued by fragmentation, subjected to ever-changing political forces, and influenced by public misunderstanding and controversy. Consensus on how to best serve people with mental health conditions remains elusive.
Dominic Sisti, Arthur Caplan, Hila Rimon-Greenspan, eds.
"In this superb volume, Sisti, Caplan, and Rimon-Greenspan have gathered in one place some of the most thoughtful and incisive thinkers about the difficulties of caring for people with mental illness. Applied Ethics in Mental Health Care is an important and timely contribution to this ongoing ethical conversation."—Paul Root Wolpe, Asa Griggs Candler Professor of Bioethics and Director of the Center for Ethics, Emory University
Michael J. Young, Dominic A. Sisti, Hila Rimon-Greenspan, Jason L. Schwartz, and Arthur L. Caplan. Nature Immunology 13, no. 6 (2012): 521-524.
Promising advances have been made in recent years for a unique class of immunotherapies that use vaccination to combat substance-use disorders. Although such vaccines are potentially useful for addictions, they raise a variety of ethical and social questions.
Naltrexone, which is sold under the trade names Depade and Revia and in an extended release version called Vivitrol, has been shown in many studies by many groups in the United States and other nations to be a very safe drug that is highly effective in treating alcoholism. Yet, relatively few programs that treat chronic alcoholics use the drug. Why?
The personal disposition of Thomas Scattergood combined with the timing of his visit to the York Retreat were profoundly fortuitous in the founding of Friends Hospital. “To Thomas Scattergood, a minister in the Society of Friends, it is generally believed that we are indebted for the inception of the institution.”